Next, to isolate the mouse from external distal visual cues, assemble an octagonal wall extending 40 centimeters above and 15 centimeters under the platform surface around the arena, positioned 10 centimeters away from the edge of the platform. Then, position a light-emitting diode, or LED, at the entrance of the shelter to provide a local visual landmark cue. Begin by attaching visual cues to the periphery of the platform, which should be at least two centimeters away from the edge to prevent mice from reaching them.Īttach the shelter to the platform. The main advantage of this paradigm is that it elicits etiologically important goal-directed navigation behavior that is triggered by well-controlled sensory stimulus, and it does not require prior training of the mice. This assay can help answer key questions in the spatial memory field, such as how animals navigate towards a recently-learned goal location.
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